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KMID : 0378019710140100101
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New Medical Journal
1971 Volume.14 No. 10 p.101 ~ p.107
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Effects of Hypophysectomy on Mast Cells in the Prostates and Seminal Vesicles of the Rats
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Abstract
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The author divided mature male Swiss albino rats, weighing about 200 gm each, into three groups of normal, sham operation, and hypophysectomy. The groups of sham operation and hypophysectomy were further divided into 1-, 2-, 3-, 5-, and 7-day subgroups, and five rats were allocated to each of the sub-groups and the normal group. The author then made observations on the behavior of the mast cells in the prostate and seminal vesicle with the following results:
1. In the normal group, the overall averages of mast cells were 91.3 in the prostate and 51.8 in the seminal vesicle, and most of the mast cells were of a rich-granule type, those of a poor-granule type and desrupted granular type being very scarce.
2. In the sham operation group, the overall average of mast cells and the ratios for types A and B cells were similar to those of the normal group.
3. The overall averages of the group of hypophysectomy, compared with the values of the group of sham operation, showed a significant increase, revealing a increase of 20-23% for the prostate in the 5￢and 7-day sub-groups, and a increase of 26-30% for the seminal vesicle in the 5- and 7-day sub-groups. In addition, the number of the degranulated cells showed a remarkable increas in the sub-groups of 3 or more post operative days.
4. It is presumed that the increase of mast cells in the group of hypophysectomy is due to the hype-r trophy of connective tissues caused by epithelial atrophy.
5. The tendency of disruptedness of granules in the mast cells in the group of hypophysectomy may he attributed to the hormonal shortage on account of the removal of the hypophysis.
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KEYWORD
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